Langridge originally came to public prominence most notably with the Judge Dredd Megazine series The Straitjacket Fits (written by David Bishop), a surreal, hallucinatory, convention-bending strip set in an insane asylum with a cast of characters who by the end had realised that they were in a comic strip and had burst out from the edge of the frame.
His cartoony art proved perfect for the series, and he has continued to work for the Megazine, in addition to a series of comedy books dedicated to his Buster Keaton-inspired character Fred the Clown, which he wrote and drew as a webcomic before self-publishing the material as small press titles. These were collected as a single volume by Fantagraphics Books in 2004. His work on Fred the Clown was nominated for two Eisner Awards, a Harvey Award, a Reuben Award and an Ignatz Award. Langridge also does illustration work.
He has also provided artwork for Shaenon Garrity's Smithson webcomic.
Langridge has provided the Fin Fang Four, with Scott Gray, first for Marvel Monsters, then a series of short stories and in late 2008 as a digital comic on Marvel Digital Comics Unlimited.
He is the cartoonist for Boom! Studios The Muppet Show (2009).