Roth serves as host of Messianic Vision, a daily radio show that can be heard on various radio stations across the United States, including KLNG (Omaha, Nebraska), KLTT (Denver), KCNW (Kansas City), KNOF (St. Paul, Minnesota), and KXEG (Phoenix). Sid Roth was a former account executive for Merrill Lynch, who became disenchanted with Judaism in 1972. Sid claimed that he became possessed by a demonic spirit guide during his New Age spiritual quest, and that a heartfelt prayer to Jesus freed him from this possession. Sid developed a theology which he calls One new man", claiming that God never intended to start a new religion, instead God intends the convergence of Jew and Gentile into one stream called the “One New Man.”

It's Supernatural TV program

Roth also has a weekly national TV program, called "It's Supernatural", featuring guests whose experiences include divine visitations, demonic possession, deliverance, and various miracles. The program can be seen on Daystar Television Network, Trinity Broadcasting Network, VisionTV (Canada), and World Harvest Television among other channels. Roth has also written numerous books, including They Thought for Themselves and his autobiography, There Must Be Something More!.