Gail L. (divine-ms-m) reviewed on 11/18/2006 + 312 more book reviews

This is an excellent account of the effects of allowing marketing of Tamnbocor (flecainide) as an anti-arrhythmic based on "surrogate" intermediate endpoints. Later there was recognition that in fact the drug was associated with increased cardiac death rates when a "gold standard" randomized controlled trial was undertaken. It also shows the problematic relationships between the payment and support of academic researchers into drug effectiveness and the drug firms, many of whose products have been life saving and life transforming. A very well balanced book and very enjoyable reading.

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