Anne Klein has been a practicing Buddhist and student of Buddhist thought since 1971, when she studied with Kensur Ngawang Lekden, the last Abbot of the Tantric College of Lower Lhasa. She then met Geshe Wangyal in New Jersey, and began studying and practicing under Khetsun Sangpo Rinpoche of Kathmandu in 1973, and receiving teaching authorization from him in 1995. She has studied extensively with a number of prominent Geluk and Dzogchen teachers in India, Nepal and the United States, including Lama Gonpo Tseten.

Dawn Mountain, co-founded with Harvey Aronson, offers a blend of traditional Tibetan Buddhist learning and practice, as well as supportive practices and cross-cultural reflection. It thus seeks to be a bridge for modern Western students seeking to understand and genuinely engage in Buddhist teachings.

In her dharma teaching, Klein emphasizes the need for embodiment in meditation practice and for an awareness that encompasses cultural as well as personal insights. Since 1998 she has been developing and leading Buddhism in the Body workshops with Phyllis Pay. These have been offered in Berkeley, Houston, Esalen Institute, and Arizona.

After graduating from Harpur College (now Binghamton University) cum laude with Highest Honors in English, Anne Klein earned her M.A. in Buddhist Studies from the University of Wisconsin—Madison and her PhD in Religious/Tibetan Studies from the University of Virginia. Following this she was awarded a Teaching and Research postdoctoral position at Harvard Divinity School as a Research Associate in Women's Studies and the History of Religion. It was here that she began work on what became her book Meeting the Great Bliss Queen, putting the significance and symbolism of Yeshe Tsogyal, a female Buddha renowned throughout Tibet, in conversation with contemporary western and feminist concerns.

Anne Klein has received National Endowment for the Humanities (NEH) translation grants and an American Council of Learned Societies (ACLS) Contemplative Studies grant. She is currently a recipient of a Ford Foundation grant under the rubric of Buddhism, Self and Gender: Traditional Buddhism and Modern Western Culture, A Living Dialogue.

She is on the Board of Directors of Ligmincha Institute, an international community for the study and preservation of Bon Buddhism founded by Geshe Tenzin Wangyal Rinpoche. She is also on the Board of Asia Society, Houston.