Moore first achieved notoriety as the writer and co-creator of Hawaiian Dick, first published in 2002 by Image Comics. Since then, he has co-created Battle Hymn, with Jeremy Haun, and The Expatriate, with Jason Latour for Image Comics, and The Leading Man, also with Jeremy Haun, for Oni Press. Moore has also written for Harris Publications, Devil's Due, Marvel Comics, DC Comics, Slave Labor Graphics, and Pennyfarthing Press.
From 2004 to 2005, Moore served as the Public Relations & Marketing Coordinator for Image Comics, before leaving the position to focus on a full-time freelance writing career.
In 2004, Hawaiian Dick was optioned by New Line Cinema for development as a feature film. That option was renewed in 2006. Also in 2006, The Leading Man was optioned by Universal Pictures.
A new Hawaiian Dick series debuted in November of 2007, with art by Scott Chantler, and covers by Hawaiian Dick co-creator Steven Griffin. The book was sub-titled "Screaming Black Thunder," and ran for five issues. Moore has mentioned his plans to continue Hawaiian Dick in a new book entitled Great Big Hawaiian Dick, but no publication date has been set as of now. Also in 2007, Moore scripted a three-issue JSA Classified story arc, featuring art by Ramon Perez, and published '76, with art by Ed Tadem, and also featuring the work of writer Seth Peck and artist Tigh Walker. Moore also contributed a story to Marvel Comics Presents, featuring the Marvel character Stingray, with art by Lee Weeks. His three-part Superman Confidential arc the same year featured art by Phil Hester and Ande Parks.
Moore's debut for WildStorm Productions was Beyond Tomorrow, a 2008 six-issue mini-series that was collected into a trade paperback in early 2009. Carlo Barberi provided the art. A planned five-issue mini-series from Top Cow Productions called Black Vault was solicited in 2009, but has yet to be released.
In July 2008, it was announced that Moore's as yet unpublished graphic novel Billy Smoke had been optioned by Warner Brothers, with actor Matthew Fox attached to star in the title role. The book is slated for a 2011 release from Oni Press, and features art by Eric Kim. In 2010 WildStorm announced the forthcoming The Further Adventures of the Whistling Skull, an upcoming creator-owned title with artist Tony Harris, set to debut in 2011.
He currently lives in suburban Kansas City with his wife and children.