Gary Wolf is perhaps best known for a series of comedic mystery novels starring the now iconic Roger Rabbit, a cartoon character who inhabits an alternate universe where so-called "toons" and humans co-exist. In 1988 his work was made into the popular film Who Framed Roger Rabbit?.

Wolf has a master's degree in advertising, given by the University of Illinois at Urbana-Champaign. Wolf and childhood friend John J. Myers, Catholic Archbishop of Newark, co-wrote a novel called Space Vulture, released from TOR books in 2008.Wolf and co-author Jehane Baptiste have a story entitled "The UnHardy Boys in Outer Space" in the annual anthology of humorous science fiction, Amityville House of Pancakes Vol 3 (ISBN 1-894-95335-5).