Scott Hampton was born in 1959 in High Point, North Carolina.

He began his career following in the footsteps of brother and fellow comic book creator Bo Hampton. Both Scott and Bo studied under Will Eisner in 1976. Scott's first professional comics work was the three-page story "Victims" published in Warren Publishing's Vampirella #101 in 1981. Scott's work on Silverheels from Pacific Comics in 1983 is regarded as the first continuing painted comic.

Working as a freelance comic book artist, Hampton has illustrated such iconic properties as Batman, Sandman, Black Widow, Hellraiser, and Star Trek in addition to work on his creator-owned projects such as The Upturned Stone.

His latest works include Spookhouse, released in 2004 by IDW Publishing, in which he adapted his favorite ghost stories into sequential form, and Batman: Gotham County Line from DC comics in 2005. Scott is currently working full time on the creator-owned series Simon Dark with writer Steve Niles for DC Comics.

Hampton has illustrated cards for the The Gathering collectible card game.

"The Upturned Stone" was optioned in Summer of 2005 for film production by David Foster Productions, but the studio lost the option and the story was recently optioned by another producer. Scott is also pursuing a passion outside of comics: film making. He completed his first short independent film "The Tontine" in April, 2006. It's his loose adaptation of a 21 page comic piece that he worked on and appeared by the same name in the Hellraiser comic series. The 29 minute film was shot at the same cabin used in Eli Roth's "Cabin Fever ". The complete short can be found on tontinefilm.com and IMDB as well as versions of it available to view on Myspace (partial), Google Video (full), and Youtube (split into 3 parts).

Scott lives with his wife Letitia in Chapel Hill, North Carolina.

Interior comics work includes:

• Silverheels (with writers April Campbell/Bruce Jones, 4-issue mini-series but only 3 were published, Pacific Comics, December 1983 - May 1984)
• Night Cries (script and art, with co-author Archie Goodwin, 96 page graphic novel, DC Comics, hardcover, 1992, ISBN 1-56389-059-3, softcover, 1993, ISBN 1-56389-066-6)
• Gen13: Bootleg #7 (Image Comics, 1997)
• Sandman Presents: Lucifer (with Mike Carey, 3-issue mini-series, Vertigo, March—May 1999)
• Batman: Gotham County Line #1-3 (with Steve Niles, 3-issue mini-series, DC Comics, 2005)
• Simon Dark #1-18 (with Steve Nile, ongoing series, DC Comics, December 2007 - May 2009)