Way received the Xeric Foundation's Xeric Grant in 2000 for his first publication, Violent Lifestyle #1. Through Violent Lifestyle, Way was introduced to Marvel Comics editor Axel Alonso, who hired Way for a Deathlok mini-series that was cancelled prior to publication.

Way's first published work for Marvel was the "Heartbreaker" storyline in Spider-Man's Tangled Web #16 & 17. This was followed by Gun Theory, a mini-series with artist Jon Proctor under the revived Epic Comics imprint. The imprint proved to be short-lived, and Gun Theory was cancelled after only two issues. Way continued to work for Marvel; his subsequent work for the publisher includes Agent X #12, Greatest Hits, Ghost Rider, the "Prelude to Planet Hulk" storyline in The Incredible Hulk, Open Season, Nighthawk, Venom, Enemy of the State, Wolverine, and Origins.

Deadpool appeared briefly in the Origins story and then Way, with artist Paco Medina, launched Deadpool (vol. 4) in September 2008, with Carlo Barberi filling in on the first issue after the Secret Invasion tie-in This was followed by the Dark Reign story "How Low Can You Go?", which also sees the return of Bob, Agent of HYDRA. After this concludes, "Magnum Opus" begins, which is a 4-issue crossover with Thunderbolts.

Comics work includes:

• Spider-Man's Tangled Web #16-17: "Heartbreaker" (with Leandro Fernández, Marvel Comics, 2002)
• Wolverine #187-189 (with John McCrea, Staz Johnson, Marvel Comics, 2003)
• Venom #1-18 (with pencils by Francisco Herrera and Skottie Young, Tsunami/Marvel Comics, 2003—2004)
• Open Season #1-4 (with pencils by Bart Sears, Marvel Comics, 2005)
• Bullseye: Greatest Hits #1-5 (with Steve Dillon, Marvel Comics, 2005)
• Nighthawk #1-6 (with Steve Dillon, Marvel Comics, 2005—2006)
• Punisher Vs. Bullseye #1-5 (with Steve Dillon, Marvel Comics, 2005—2006)
• The Incredible Hulk #88-93 (with pencils by Carlo Pagulayan, Marvel Comics, 2006)
• Ghost Rider (vol. 6) #1-19 (Marvel Comics, 2006—2009)
• Wolverine (vol. 2) #33-40( with Javier Saltares, Marvel Comics, 2005—2006)
• Origins #1-50 (with Steve Dillon and Mike Deodato, Marvel Comics, 2006—2010)
• Deadpool (vol. 2) #1- (with Paco Medina, Marvel Comics, 2008-ongoing)
• Starr the Slayer #1-3 (with pencils by Richard Corben, Marvel Comics, 2009—2010)
• Hit-Monkey (vol. 1) #1- (with Dalibor Talajic, Marvel Comics, 2010 -ongoing)