Since 2003, McKelvie has collaborated with journalist Kieron Gillen on a comic strip for the official Playstation Magazine UK, entitled Save Point. He has worked on a number of projects for Image Comics, including the six-issue series Phonogram. His next major work was with colorist Guy Major and Matthew Wilson on his creator-owned series Suburban Glamour, and in advance of the first issue, Jamie was dubbed "one of the major new talents of the decade" by Warren Ellis.
He has done art and covers for several comics, including X-Men and Hack/Slash. His current major work is a sequel to Phonogram, called Phonogram - Singles Club, being published over 2008-2010. In February and March 2009, he drew issues 11 and 12 of Cable for Marvel and 5 pages for Gotham Gazette: Batman Dead? for DC.