Salicrup began his comics career at Marvel Comics, where he started out as a messenger and worked his way up to editor. A Marvel employee for twenty years, he edited The Uncanny X-Men up to the death of Phoenix; Fantastic Four; Avengers; Todd McFarlane's Spider-Man; Marvel Age magazine for eight years; and many other titles; as well as writing Transformers, Sledge Hammer, The A-Team, the Marvel Toilet Paper, Spidey Super Stories, and the child abuse prevention issue of Spider-Man.

Salicrup was also editor-in-chief of Topps Comics, where he edited Bram Stoker's Dracula, X-Files, The Lone Ranger and Tonto, Zorro, Lady Rawhide, a line of Jack Kirby superhero titles, Ray Bradbury Comics, and more.

At Stan Lee Media, Salicrup served as senior writer/editor, as well as the writer and voice of "Stan Lee's Evil Clone".

Salicrup is the editor-in-chief at Papercutz, publishers of Nancy Drew, The Hardy Boys, Tales From The Crypt, Totally Spies!, and Zorro graphic novels.

He is also a trustee at the Museum of Comic and Cartoon Art (MoCCA).

The name "Salicrup" was used as a unit of measuring time in DC Comics' R.E.B.E.L.S. issue #8, November 2009.