A former agoraphobic, Bassett founded the Midwest Center for Stress and Anxiety headquartered in Oak Harbor, Ohio in 1984. She is the creator of "Attacking Anxiety and Depression", which is a 15-week home study course about recovery from anxiety disorders such as agoraphobia and panic attacks. Though she has published and produced several products, the program "Attacking Anxiety and Depression" is Bassett's most known product. The program is a 15-week workshop for recovery from anxiety disorder and clinical depression, which Bassett claims often co-exist within the sufferer. Participants may use the program by attending in-person workshops, by purchasing an audio version, through one-on-one counseling or via the company's web site. The program advocates an approach that is cognitive, rather than pharmaceutical. Bassett places emphasis upon relaxation techniques and what she refers to as "positive thinking" as a means of recovery.

Bassett's flagship infomercial has aired on late-night television for over a decade. She has appeared on many national (U.S.) talk shows, including the Oprah Winfrey Show, The View, the Montel Williams Show and Hour of Power. In addition, her work has been featured in several (U.S.) magazine publications, including Family Circle, Reader's Digest, and The Journal of Clinical Psychology.

Bassett is the mother of two, Brittany and Sammy, and lives in Malibu, California. Bassett's husband, David Bassett, died on June 7, 2008 at the age of 53 of an apparent suicide.