• National Cartoonist Society’s Reuben for Cartoonist of the Year 1999
• National Cartoonist Society’s Award for Comic Strip of the Year 1996
• National Cartoonist Society's Reuben Award (nominee) 1997 and 1998
• Germany’s Max and Moritz Award for Best International Comic Strip 1998
• Swedish Academy of Comic Art’s Adamson Statuette 1997
• Harvey Award for Best Comic Strip 1997, 1999, 2001, 2002, 2003
• Ark Trust Genesis Award 1997, 1999
• PETA Humanitarian Award 2001
• National Cartoonist Society Award for Greeting Cards 1991
• National Cartoonist Society Award for Magazine and Book Illustration 1991

MUTTS Strip collections

1. MUTTS (1996)
2. Cats & Dogs (1997)
3. More Shtuff (1998)
4. Yesh! (1999)
5. Our MUTTS (2000)
6. A Little Look-See (2001)
7. What Now (2002)
8. I Want To Be The Kitty! (2003)
9. Dog-Eared (2004)
10. Who Let The Cat Out? (2005)
11. Everyday MUTTS: A Comic Strip Treasury (2006) (Sundays in color)
12. Animal Friendly: A MUTTS Treasury (2007) (Sundays in color)
13. Call of The Wild: A MUTTS Treasury (2008) (Sundays in color)

MUTTS Sunday Collections (large format, in color)

• MUTTS Sundays (1999)
• Sunday Mornings (2001)
• Sunday Afternoons (2004)
• Sunday Evenings (2005)

Other

• Bad Baby (1988) (collection of Bad Baby strips from Parent Magazine)
• MUTTS Little Big Book (1998)
• MUTTS: The Comic Art of Patrick McDonnell (2003) (retrospective)
• The Best of MUTTS (2007) (retrospective)
• MUTTS: Shelter Stories: Love. Guaranteed. ([2008]) Collection of over 100 Shelter Stories strips accompanied by photos and vignettes of adopted pets
• Guardians of Being (2009) (Words by Eckhart Tolle)

• The Gift of Nothing (2005), New York Times Bestseller (original MUTTS book)
• Art (2006)(original book)
• Just Like Heaven (2006) (original MUTTS book)
• Hug Time (2007), New York Times Bestseller (original MUTTS book)
• South (2008)
• Wag! (2009) (original MUTTS book)