Eckler's work has appeared in ELLE, Fashion, Maclean's, Lifestyles, Canadian House and Home and Mademoiselle. She was the host of the short-lived television show Modern Manners, and has appeared on CTV and CBC television, and on Global television as a reporter.

Eckler was employed by the National Post from 2000 to 2005, when she was among a number of staff let go by the CanWest newspaper chain.The announcement "Rebecca Eckler is pregnant" was headlined by the Post on its front page.

From March 2006 to May 2007, Eckler wrote "Mommy blogger", a weekly freelance piece in the Globe and Mail. Currently Eckler is a columnist for Post City Magazines in Toronto. From 2003 until April 2008 she wrote Post City's Shopgirl column. In May 2008 the column was given to Post City associate editor Karen Aagaard.

Eckler became pregnant on the night of her engagement party and published the 2004 book Knocked Up: Confessions of a Hip Mother-to-Be.

Prior to the book's publication, The New York Times published a piece written by Eckler about falling for another man while pregnant with her fiancé's child.

In April 2007, Eckler followed Knocked Up with Wiped! Life with a Pint-Sized Dictator which chronicles her first two years of motherhood.

In mid-2007, she announced in Maclean's that she had filed a lawsuit against Universal Studios alleging copyright infringement due to alleged similarities between her book and the 2007 comedy film Knocked Up.

Although reviewed positively on "mommy blogs", Wiped! received mostly negative reviews in Canadian dailies. Quill & Quire, Canada's foremost trade/literary magazine, gave the book a particularly scathing review.

Eckler's blog, NinePoundDictator, prompted the creation of a parody blog, NineGramBrain, which was noted in The Toronto Star. The site lasted until December 2007.

In an interview for ParentsCanada magazine, Eckler discusses how she likes to be controversial and is now a single mom who has a regular nanny to do housework.

In 2007, Eckler participated in a charity auction for the magazine The Walrus, paying $7,000 for the right to have a character in Margaret Atwood's novel The Year of the Flood named after her.